Interleukin-33 exacerbates acute colitis via interleukin-4 in mice
نویسندگان
چکیده
منابع مشابه
Interleukin-6 exacerbates early atherosclerosis in mice.
Acute-phase proteins, which respond to systemic proinflammatory cytokines such as interleuken-6, are elevated in cardiovascular disease and are predictive markers of future ischemic events, even over decades. This suggests a role for proinflammatory cytokines and/or acute phase proteins in early lesion development. To explore this issue, we fed C57Bl/6 and nonobese diabetic male mice high-fat (...
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BACKGROUND The regulation and function of IgE in healthy individuals and in antigen-naïve animals is not well understood. IL-33 administration increases serum IgE in mice with unknown mechanism. We tested the hypothesis that IL-33 provides an antigen-independent stimulus for IgE production and mast cell degranulation. METHODS IL-33 was administered to naïve wild-type (WT), nude and ST2(-/-) ,...
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Interleukin (IL)-33 is a member of the IL-1 family of cytokines. IL-33 is expressed in nuclei and secreted as alarmin upon cellular damage to deliver a danger signal to the surrounding cells. Previous studies showed that IL-33 is expressed in the brain and that it is involved in neuroinflammatory and neurodegenerative processes in both humans and rodents. Nevertheless, the role of IL-33 in phys...
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ژورنال
عنوان ژورنال: Immunology
سال: 2013
ISSN: 0019-2805
DOI: 10.1111/imm.12111